Dandy Journal

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sciencenote: Robotic machinery, such as this Tecan Freedom Evo, are necessary for biomedical systems studies carried out by Haiyuan Yu’s. From left, Xiujuan Wang, Xiaomu Wei, Haiyuan Yu, and Jishnu Das. The goal is to find the mutations that drive such diseases as cancer and other complex genetic diseases, said Haiyuan Yu, an assistant professor in the Department of Biological Statistics and Computational Biology and the
 Weill Institute for Cell and Molecular Biology and the paper’s senior author. Xiujuan Wang, a postdoctoral researcher in Yu’s lab, is the paper’s lead author.  …..For example, in an analysis of colorectal cancer, Yu and colleagues found that out of nine genetic mutations that affect two proteins involved in DNA repair, three of those mutations showed up on the interface areas of the two proteins. “If they are on the interface, they are more likely to be drivers of disease,” Yu said. “Then we did experiments that completely verified the computational analysis,” he added. The method can be applied to any disease, mutation and protein, he said.

sciencenote:

Robotic machinery, such as this Tecan Freedom Evo, are necessary for biomedical systems studies carried out by Haiyuan Yu’s. From left, Xiujuan Wang, Xiaomu Wei, Haiyuan Yu, and Jishnu Das.

The goal is to find the mutations that drive such diseases as  and other complex , said Haiyuan Yu, an assistant professor in the Department of Biological Statistics and  and the
 Weill Institute for Cell and Molecular Biology and the paper’s senior author. Xiujuan Wang, a postdoctoral researcher in Yu’s lab, is the paper’s lead author.

 …..For example, in an analysis of colorectal cancer, Yu and colleagues found that out of nine  that affect two proteins involved in DNA repair, three of those mutations showed up on the interface areas of the two proteins. “If they are on the interface, they are more likely to be drivers of disease,” Yu said. “Then we did experiments that completely verified the computational analysis,” he added.

The method can be applied to any disease, mutation and protein, he said.

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